Computation in Biological Systems

The primary objective of the laboratory is to uncover the fundamental principles of how the biological systems process information, from the evolutionary perspective of adaptation and natural selection. In particular, we studies systems in two categories: (1) the sensory encoding and representation, and, (2) the gene expression and regulation.

Dr. Dawei W. Dong
Department of Biomedical Sciences
University of Pennsylvania
Philadelphia, PA 19104

Phone: (215) 898-9228
Cell : (561) 703-9039

Selected Publications:
  1. Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development by Junling Wang, Iuliia Pavlyk, Pavan Vedula, Stephanie Sterling, N. Adrian Leu, Dawei W. Dong, Anna Kashina, Developmental Biology, v430.1, p41-51, doi:10.1016/j.ydbio.2017.08.027. (Abstract and Online Paper)

  2. Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration by Junling Wang, Xuemei Han, Nicolae Adrian Leu, Stephanie Sterling, Satoshi Kurosaka, Marie Fina, Virginia M. Lee, Dawei W. Dong, John R. Yates III, Anna Kashina, Scientific Reports, v7, 11323, doi:10.1038/s41598-017-11713-z. (Abstract and Online Paper)

  3. Disruption of cytochrome c oxidase function induces Warburg effect and metabolic reprogramming by Satish Srinivasan, Manti Guha, Dawei W. Dong, Kelly A. Whelan, Gordon Ruthel, Yasuto Uchikado, Shoji Natsugoe, Hiroshi Nakagawa, Narayan G. Avadhani, Oncogene, v35, p1585-1595, doi:10.1038/onc.2015.227. (Abstract and Online Paper)

  4. Arginyltransferase ATE1 suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers by Reena Rai, Fangliang Zhang, Kristen Colavita, Nicolae Adrian Leu, Satoshi Kurosaka, Akhilesh Kumar, Michael D. Birnbaum, Balazs Gyorffy, Dawei W. Dong, Michael Shtutman, Anna Kashina, Oncogene, v35, p4058-4068, doi:10.1038/onc.2015.473. (Abstract and Online Paper)

  5. Defects of cytochrome c oxidase expression induces a metabolic shift to glycolysis and carcinogenesis by Dawei W. Dong, Satish Srinivasan, Manti Guha, Narayan G. Avadhani, Genomics Data, v6, p99-107, doi:10.1016/j.gdata.2015.07.031. (Abstract and Online Paper)

  6. Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints by Dawei W. Dong, Filipe Pereira, Steven P. Barrett, Jill E. Kolesar, Kajia Cao, Joana Damas, Liliya A. Yatsunyk, F. Brad Johnson, and Brett A. Kaufman, BMC Genomics, doi:10.1186/1471-2164-15-677. (Abstract, PDF and Online Paper)

  7. Maximizing causal information of natural scenes in motion by Dawei W. Dong, In: Dynamics of Visual Motion Processing (Ilg UJ and Masson GS eds), p261-282, doi:10.1007/978-1-4419-0781-3_12, (Abstract, PDF and Online Book)

  8. Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development by Reena Rai, Catherine C. L. Wong, Tao Xu, N. Adrian Leu, Dawei W. Dong, Caiying Guo, K. John McLaughlin, John R. Yates, III, and Anna Kashina, Development, v135.23, p3881-3889. (Abstract, PDF and Online Paper)